Optimization of pressurized liquid extraction of three major acetophenones from Cynanchum bungei using a box-behnken design.
Int J Mol Sci
; 13(11): 14533-44, 2012 Nov 08.
Article
em En
| MEDLINE
| ID: mdl-23203079
ABSTRACT
In this work, pressurized liquid extraction (PLE) of three acetophenones (4-hydroxyacetophenone, baishouwubenzophenone, and 2,4-dihydroxyacetophenone) from Cynanchum bungei (ACB) were investigated. The optimal conditions for extraction of ACB were obtained using a Box-Behnken design, consisting of 17 experimental points, as follows Ethanol (100%) as the extraction solvent at a temperature of 120 °C and an extraction pressure of 1500 psi, using one extraction cycle with a static extraction time of 17 min. The extracted samples were analyzed by high-performance liquid chromatography using an UV detector. Under this optimal condition, the experimental values agreed with the predicted values by analysis of variance. The ACB extraction yield with optimal PLE was higher than that obtained by soxhlet extraction and heat-reflux extraction methods. The results suggest that the PLE method provides a good alternative for acetophenone extraction.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Acetofenonas
/
Extratos Vegetais
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Cynanchum
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Extração Líquido-Líquido
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article