Quasi equilibrium approximations of the fixation index under neutrality: the finite and infinite island models.
Theor Popul Biol
; 84: 9-24, 2013 Mar.
Article
em En
| MEDLINE
| ID: mdl-23220398
ABSTRACT
The fixation index F(ST) and the coefficient of gene differentiation G(ST) are analyzed for the finite island model under short time spans, ignoring mutations. Dividing the reproduction cycle into the three steps-gamete formation, fertilization, and migration-we develop a new approach for computing quasi equilibrium formulas for F(ST) (and G(ST)). Our formulas generalize earlier ones and reveal that the equilibrium value of F(ST) is influenced not only by the migration rate and local effective population size, N(e), but also by the local census size N, particularly so when the migration rate is high. The order of migration and fertilization is found to have a smaller effect on F(ST). A major advantage compared to previous approaches is that stochastic allele frequency of migrants is easily accommodated, thereby avoiding underestimation of F(ST) for large migration rates.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Variação Genética
/
Genética Populacional
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Modelos Teóricos
Limite:
Female
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Humans
/
Male
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article