Role of ventral subiculum in context-induced reinstatement of heroin seeking in rats.
Addict Biol
; 19(3): 338-42, 2014 May.
Article
em En
| MEDLINE
| ID: mdl-23231571
ABSTRACT
In rats, reexposure to heroin-paired contexts after extinction of lever responding in a different context reinstates heroin seeking. Previous reports indicate that ventral hippocampus/Ca1 region plays a critical role in cocaine-, cue- and context-induced reinstatement of cocaine seeking. Here, we examined whether ventral subiculum, the output region of ventral hippocampus, is involved in context-induced reinstatement of heroin seeking. We found that reversible inactivation of ventral subiculum, but not posterior Ca1, with the gamma-aminobutyric acid agonists muscimol + baclofen decreased context-induced reinstatement of heroin seeking. Our findings, together with previous studies on cocaine seeking, indicate a critical role of ventral subiculum in context-induced relapse across drug classes.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dependência de Heroína
/
Hipocampo
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article