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MAP3K8 kinase regulates myeloma growth by cell-autonomous and non-autonomous mechanisms involving myeloma-associated monocytes/macrophages.
Hebron, Ellen; Hope, Chelsea; Kim, Jaehyup; Jensen, Jeffrey L; Flanagan, Claire; Bhatia, Neehar; Maroulakou, Ioanna; Mitsiades, Constantine; Miyamoto, Shigeki; Callander, Natalie; Hematti, Peiman; Asimakopoulos, Fotis.
Afiliação
  • Hebron E; Department of Medicine, Division of Hematology/Oncology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
Br J Haematol ; 160(6): 779-84, 2013 Mar.
Article em En | MEDLINE | ID: mdl-23252623
ABSTRACT
Benefit from cytotoxic therapy in myeloma may be limited by the persistence of residual tumour cells within protective niches. We have previously shown that monocytes/macrophages acquire a proinflammatory transcriptional profile in the myeloma microenvironment. Here we report constitutive activation of MAP3K8 kinase-dependent pathways that regulate the magnitude and extent of inflammatory activity of monocytes/macrophages within myeloma niches. In myeloma tumour cells, MAP3K8 acts as mitogen-induced MAP3K in mitosis and is required for TNFα-mediated ERK activation. Pharmacological MAP3K8 inhibition results in dose-dependent, tumour cell-autonomous apoptosis despite contact with primary stroma. MAP3K8 blockade may disrupt crucial macrophage-tumour cell interactions within myeloma niches.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Monócitos / Proteínas Proto-Oncogênicas / MAP Quinase Quinase Quinases / Macrófagos / Mieloma Múltiplo Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2013 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Monócitos / Proteínas Proto-Oncogênicas / MAP Quinase Quinase Quinases / Macrófagos / Mieloma Múltiplo Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2013 Tipo de documento: Article