Reevaluation of the safety of induced pluripotent stem cells: a call from somatic mosaicism.
Protein Cell
; 4(2): 83-5, 2013 Feb.
Article
em En
| MEDLINE
| ID: mdl-23264042
ABSTRACT
Recent studies have been raising doubts on the safety of induced pluripotent stem cells (iPSCs) and proposing that the process of reprogramming brought about copy number variations (CNVs) in iPSCs. However, a recent paper published in Nature provided evidence showing that most CNVs were pre-existed as somatic mosaicism but not resulted from the reprogramming. This new finding would profoundly reshape some previous thoughts and endorse the confidence of iPSCs in both research and therapy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco Pluripotentes Induzidas
/
Mosaicismo
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article