[Aryl hydrocarbon receptor interacting protein gene and familial isolated pituitary adenomas].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
; 34(6): 640-4, 2012 Dec.
Article
em Zh
| MEDLINE
| ID: mdl-23286415
ABSTRACT
Familial isolated pituitary adenoma (FIPA) is an autosomal dominant disease, characterized by low penetrance, early-onset disease, more invasive tumor growth, as well as somatotroph and lactotroph adenomas in most cases. It has been indicated that the aryl hydrocarbon receptor interacting protein (AIP) gene is a tumor suppressor gene. Many heterozygous mutations have been discovered in AIP in about 20% of FIPA families. However, the exact molecular mechanism by which its disfunction promotes tumorigenesis of pituitary is unclear.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Hipofisárias
/
Peptídeos e Proteínas de Sinalização Intracelular
/
Adenoma Hipofisário Secretor de Hormônio do Crescimento
Limite:
Humans
Idioma:
Zh
Ano de publicação:
2012
Tipo de documento:
Article