Resveratrol suppresses tumor progression via the regulation of indoleamine 2,3-dioxygenase.
Biochem Biophys Res Commun
; 431(2): 348-53, 2013 Feb 08.
Article
em En
| MEDLINE
| ID: mdl-23291179
ABSTRACT
This study showed the potential of resveratrol to inhibit the expression and activity of interferon-γ (IFN-γ)-induced indoleamine 2,3-dioxygenase (IDO) in bone marrow-derived dendritic cells (BMDCs). The mechanism of suppression was associated with the activity of Janus kinase/signal transducers and activators of transcription (JAK/STAT) and protein kinase Cδ (PKCδ). In addition, resveratrol-mediated IDO suppression in IFN-γ-stimulated BMDCs appears to play a pivotal role in anti-tumor activity through the regulation of CD8(+) T cell polarization and cytotoxic T lymphocyte (CTL) activity. Systemic administration of resveratrol suppressed tumor growth in EG7 thymoma-bearing mice in an IDO-dependent manner. Taken together, resveratrol not only regulates immune response through the regulation of IDO in a JAK/STAT1- and PKCδ-dependent manner, but also modulates the IDO-mediated immune tolerance in EG7 thymoma.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estilbenos
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Células Dendríticas
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Linfócitos T CD8-Positivos
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Evasão Tumoral
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Indolamina-Pirrol 2,3,-Dioxigenase
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Neoplasias
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article