Genetic polymorphism for IFNγ +874T/A in patients with acute toxoplasmosis.
Rev Soc Bras Med Trop
; 45(6): 757-60, 2012 Dec.
Article
em En
| MEDLINE
| ID: mdl-23295883
ABSTRACT
INTRODUCTION:
A single nucleotide polymorphism (SNP) in the gene encoding gamma interferon influences its production and is associated with severity of infectious diseases. This study aimed to evaluate the association of IFNγ+874T/A SNP with duration of disease, morbidity, and development of retinochoroiditis in acute toxoplasmosis.METHODS:
A case-control study was conducted among 30 patients and 90 controls.RESULTS:
Although statistical associations were not confirmed, A-allele was more common among retinochoroiditis cases and prolonged illness, while T-allele was more frequent in severe disease.CONCLUSIONS:
Despite few cases, the results could indicate a relation between IFNγ+874T/A single nucleotide polymorphism and clinical manifestations of toxoplasmosis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Toxoplasmose
/
Coriorretinite
/
Interferon gama
/
Polimorfismo de Nucleotídeo Único
/
Frequência do Gene
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article