An unsaturated aliphatic alcohol as a natural ligand for a mouse odorant receptor.
Nat Chem Biol
; 9(3): 160-2, 2013 Mar.
Article
em En
| MEDLINE
| ID: mdl-23314914
ABSTRACT
We report the identification of a physiological receptor-volatile pair in the mouse olfactory system. By activity-guided fractionation of exocrine gland extracts and subsequent chemical analysis, (Z)-5-tetradecen-1-ol was identified as a natural ligand for a mouse odorant receptor. (Z)-5-tetradecen-1-ol is excreted into male mouse urine under androgen control and enhances urine attractiveness to female mice. This report is to our knowledge the first to describe natural product-based deorphanization of an odorant receptor.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Produtos Biológicos
/
Receptores Odorantes
/
Álcoois Graxos
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article