Parathyroid hormone-independent hypercalcemia in an infant with renal dysplasia: possible role of PTHrP.
J Pediatr Endocrinol Metab
; 26(3-4): 365-7, 2013.
Article
em En
| MEDLINE
| ID: mdl-23327815
ABSTRACT
BACKGROUND:
Parathyroid hormone (PTH)-independent hypercalcemia in patients with chronic kidney failure is a rare and poor understood entity. CASE REPORT We report the case of an infant with stage III chronic kidney failure secondary to multicystic dysplastic kidney disease, who presented at 3 months of life with severe hypercalcemia, suppressed PTH, and elevated PTH-related peptide. Malignancy was discarded, and the patient was treated twice with bisphosphonates with an initial partial response. During follow-up, the calcium levels descended. To date, he has maintained normal serum calcium level for 1 year after discharge.CONCLUSIONS:
The presence of PTH-related peptide may play a role in hypercalcemia associated to multicystic dysplastic kidney disease possibly by the overproduction of this peptide in the kidney.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hormônio Paratireóideo
/
Rim Displásico Multicístico
/
Proteína Relacionada ao Hormônio Paratireóideo
/
Hipercalcemia
/
Falência Renal Crônica
Limite:
Humans
/
Infant
/
Male
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article