Effects of cold acclimation on the energetic metabolism of the staggerer mutant mouse.
Physiol Behav
; 47(2): 377-80, 1990 Feb.
Article
em En
| MEDLINE
| ID: mdl-2333349
ABSTRACT
Staggerer mutant mice are lean despite their hyperphagia. Brown adipose tissue activity may be implicated in this phenomenon. The aim of this work is to determine the energetic metabolism and to detail some characteristics of the brown adipose tissue of Staggerer mutant mice born and reared either at 28 degrees C (within the thermoneutral zone) or 22 degrees C (cold temperature) compared to nonmutant control mice. In mutant mice reared at thermoneutrality the resting metabolism was found to be higher than that of controls, and further the activity of the brown adipose tissue increased as indicated in relative mass, composition and cytochrome oxydase activity. A stimulatory effect of cold exposure was observed in both mutant and nonmutant mice. It is suggested that Staggerer mice may provide a good model for the study of the cold-induced or diet-induced mechanisms of brown fat stimulation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Regulação da Temperatura Corporal
/
Cerebelo
/
Metabolismo Energético
/
Aclimatação
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article