A sterically demanding organo-superbase avoids decomposition of a naked trifluoromethyl carbanion directly generated from fluoroform.
Org Biomol Chem
; 11(9): 1446-50, 2013 Mar 07.
Article
em En
| MEDLINE
| ID: mdl-23344691
ABSTRACT
A simple strategy avoiding the decomposition of a naked trifluoromethyl anion to difluorocarbene by a sterically very demanding organo-superbase without the help of a trifluoromethyl anion reservoir such as DMF is reported. The direct non-metallic trifluoromethylation of carbonyl compounds using fluoroform in the presence of t-Bu-P4 base afforded trifluoromethyl alcohols in high yields.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Álcoois
/
Clorofluorcarbonetos de Metano
/
Hidrocarbonetos Fluorados
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article