Meta-analysis identifies a MECOM gene as a novel predisposing factor of osteoporotic fracture.
J Med Genet
; 50(4): 212-9, 2013 Apr.
Article
em En
| MEDLINE
| ID: mdl-23349225
ABSTRACT
BACKGROUND:
Osteoporotic fracture (OF) as a clinical endpoint is a major complication of osteoporosis. To screen for OF susceptibility genes, we performed a genome-wide association study and carried out de novo replication analysis of an East Asian population.METHODS:
Association was tested using a logistic regression analysis. A meta-analysis was performed on the combined results using effect size and standard errors estimated for each study.RESULTS:
In a combined meta-analysis of a discovery cohort (288 cases and 1139 controls), three hospital based sets in replication stage I (462 cases and 1745 controls), and an independent ethnic group in replication stage II (369 cases and 560 for controls), we identified a new locus associated with OF (rs784288 in the MECOM gene) that showed genome-wide significance (p=3.59×10(-8); OR 1.39). RNA interference revealed that a MECOM knockdown suppresses osteoclastogenesis.CONCLUSIONS:
Our findings provide new insights into the genetic architecture underlying OF in East Asians.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteoporose
/
Fatores de Transcrição
/
Proto-Oncogenes
/
Locos de Características Quantitativas
/
Proteínas de Ligação a DNA
/
Fraturas por Osteoporose
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Aged
/
Humans
/
Middle aged
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article