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Rearrangement of the human ABL oncogene in a glioblastoma.
Heisterkamp, N; Morris, C; Sender, L; Knoppel, E; Uribe, L; Cui, M Y; Groffen, J.
Afiliação
  • Heisterkamp N; Section of Molecular Genetics, Children's Hospital, Los Angeles, California 90027.
Cancer Res ; 50(11): 3429-34, 1990 Jun 01.
Article em En | MEDLINE | ID: mdl-2334939
ABSTRACT
A number of protooncogenes have been implicated in human tumorigenesis. The ABL oncogene is consistently rearranged and activated as a consequence of the translocation t(9;22) that gives rise to the Philadelphia chromosome in chronic myeloid leukemia and in some cases of acute lymphoblastic leukemia. Here we describe rearrangement of ABL in a different type of malignancy. The glioblastoma cell line A172 lacks germline alleles of ABL. A recombination event, presumably followed by a duplication, has created two ABL alleles in which exon 11 is joined to chromosome 16 sequences. Although the main body of ABL exons was still present, two considerably shortened ABL mRNAs of 3.8 and 2.8 kilobases were detected; the 3.8-kilobase mRNA hybridized exclusively to an exon IB probe. Neither mRNA hybridized to an ABL probe encompassing part of the tyrosine kinase domain. Thus, the cell line A172 is able to survive in the absence of a functional ABL gene product, indicating that the role of ABL is unlikely to be "housekeeping."
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oncogenes / Translocação Genética / Cromossomos Humanos Par 9 / Cromossomos Humanos Par 16 / Rearranjo Gênico / Glioma Limite: Humans Idioma: En Ano de publicação: 1990 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oncogenes / Translocação Genética / Cromossomos Humanos Par 9 / Cromossomos Humanos Par 16 / Rearranjo Gênico / Glioma Limite: Humans Idioma: En Ano de publicação: 1990 Tipo de documento: Article