Target gene sequencing to define the susceptibility of Neisseria meningitidis to ciprofloxacin.
Antimicrob Agents Chemother
; 57(4): 1961-4, 2013 Apr.
Article
em En
| MEDLINE
| ID: mdl-23357770
ABSTRACT
Meningococcal gyrA gene sequence data, MICs, and mouse infection were used to define the ciprofloxacin breakpoint for Neisseria meningitidis. Residue T91 or D95 of GyrA was altered in all meningococcal isolates with MICs of ≥ 0.064 µg/ml but not among isolates with MICs of ≤ 0.032 µg/ml. Experimental infection of ciprofloxacin-treated mice showed slower bacterial clearance when GyrA was altered. These data suggest a MIC of ≥ 0.064 µg/ml as the ciprofloxacin breakpoint for meningococci and argue for the molecular detection of ciprofloxacin resistance.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA Girase
/
Infecções Meningocócicas
/
Anti-Infecciosos
/
Antibacterianos
/
Neisseria meningitidis
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article