Does sildenafil contribute to acute coronary thrombosis?
Turk Kardiyol Dern Ars
; 40(6): 536-9, 2012 Sep.
Article
em En
| MEDLINE
| ID: mdl-23363902
ABSTRACT
Sildenafil was the first oral compound to be approved for the treatment of erectile dysfunction. It is a selective inhibitor of isoform 5 of phosphodiesterase, which is the enzyme responsible for the breakdown of 3', 5'-cyclic guanosine mono-phosphate. Sildenafil-associated myocardial infarction (MI) is rarely seen in patients without previous history of coronary artery disease. A 43-year-old man presented with sudden onset of chest pain. It was determined that his chest pain started after sildenafil intake. Findings consistent with acute anterior MI were observed on electrocardiography. Coronary angiography showed total occlusion of left anterior descending artery with thrombosis. Coronary angioplasty and stenting was successfully performed.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Trombose Coronária
/
Citrato de Sildenafila
Limite:
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article