[Effect of modifiers of natural biological response on the functional activity of macrophages (oncological aspect)]. / Vliianie modifikatorov biologicheskogo otveta prirodnogo proiskhozhdeniia na funktsional'nuiu aktivnost' makrofagov (onkologicheskii aspekt).
Antibiot Khimioter
; 35(2): 29-33, 1990 Feb.
Article
em Ru
| MEDLINE
| ID: mdl-2337372
ABSTRACT
Induction of cytotoxicity by biological response modifiers (BRMs) is only one aspect of macrophage activation. After the use of BRMs there were other changes in the functional activity of cells and in particular their increased production or secretion of a number of growth factors. Thus, activation of macrophage antitumor activity induced by BCG vaccine was transitory while activation of growth factor production was more stable in time which finally led to increased proliferation of tumor cells. Combined use of cyclophosphamide and BCG vaccine significantly increased not only the toxicity induced by BCG vaccine but also their liberation of the growth factors. Such macrophages lost their ability to control the growth of a small number of the tumor cells cultivated in their presence. Development of ways for directed activation of macrophages aimed at elimination of the tumor cells which survived the chemotherapy should include evaluation of the combined effect of various BRMs and chemotherapeutics on both antitumor and protumor activity i. e. ability to produce the factors stimulating the tumor growth.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vacina BCG
/
Ciclofosfamida
/
Macrófagos
/
Mieloma Múltiplo
/
Neoplasias Experimentais
Limite:
Animals
Idioma:
Ru
Ano de publicação:
1990
Tipo de documento:
Article