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Inflammatory acne management with a novel prescription dietary supplement.
Shalita, Alan R; Falcon, Ronald; Olansky, Alan; Iannotta, Patricia; Akhavan, Arash; Day, Doris; Janiga, Anthony; Singri, Prashant; Kallal, John E.
Afiliação
  • Shalita AR; Department of Dermatology, SUNY Downstate Medical Center, Brooklyn, NY, USA.
J Drugs Dermatol ; 11(12): 1428-33, 2012 Dec.
Article em En | MEDLINE | ID: mdl-23377512
BACKGROUND: Inflammatory acne, particularly in post-adolescent women, is increasing in incidence. The most effective therapeutic modality for treatment of this type of acne has been the administration of oral tetracyclines. Long-term acne treatment with such drugs, however, is frequently accompanied by undesirable adverse reactions, including gastrointestinal disturbances, antianabolic effects, headaches, tinnitus, and photosensitivity. OBJECTIVE: To assess the usefulness of a novel dietary supplement in the overall management of patients with inflammatory acne vulgaris. METHODS: 235 patients with inflammatory acne vulgaris were enrolled by dermatologists in a multicenter, open-label, 8-week, prospective study evaluating the effects of adding NicAzel, 1 to 4 tablets daily, to their current acne treatment regimen. RESULTS: A statistically significant (P<.0001) number of patients demonstrated improvement over their previous acne treatment regimens after both 4 and 8 weeks of NicAzel (nicotinamide, azelaic acid, zinc, pyridoxine, copper, folic acid; Elorac Inc, Vernon Hills, IL) use. At week 8, 88% of the patients experienced a visible reduction in inflammatory lesions, and 81% of the patients rated their appearance as much or moderately better compared with baseline. Three-quarters (76%) of the patients thought NicAzel was at least as effective as previous treatment with oral antibiotics. CONCLUSION: Patients with inflammatory acne showed significant improvement in acne severity and overall appearance when NicAzel was added to their existing treatment regimen.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridoxina / Zinco / Niacinamida / Acne Vulgar / Cobre / Suplementos Nutricionais / Ácidos Dicarboxílicos / Ácido Fólico Tipo de estudo: Clinical_trials / Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2012 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridoxina / Zinco / Niacinamida / Acne Vulgar / Cobre / Suplementos Nutricionais / Ácidos Dicarboxílicos / Ácido Fólico Tipo de estudo: Clinical_trials / Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2012 Tipo de documento: Article