[Unusual work schedule: mathematical and pharmacokinetic models to adjust the occupational exposure limit of the chemical agents]. / Modelli matematici e farmacocinetici per il calcolo del fattore di adattamento del valore limite degli agenti chimici.

ABSTRACT

Exposure to chemicals in unusual work shifts can require adjustment of the occupational limit values to assure adequate protection of the exposed workers. The study introduces a comparative analysis of the mathematical and pharmacokinetic models to calculate the adjustment factors and provides a computer-assisted toolkit to obtain the reduction factors for exposures to single chemical agent and mixtures in unusual work schedule.