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Maturin acetate from Psacalium peltatum (Kunth) Cass. (Asteraceae) induces immunostimulatory effects in vitro and in vivo.
Juárez-Vázquez, María del Carmen; Alonso-Castro, Angel Josabad; Rojano-Vilchis, Nadia; Jiménez-Estrada, Manuel; García-Carrancá, Alejandro.
Afiliação
  • Juárez-Vázquez Mdel C; División de Investigación Básica, Instituto Nacional de Cancerología, DF, Mexico.
Toxicol In Vitro ; 27(3): 1001-6, 2013 Apr.
Article em En | MEDLINE | ID: mdl-23395935
ABSTRACT
Maturin acetate (MA) is one of main constituents in Psacalium peltatum. The cytotoxic effects of MA on tumorigenic cells were evaluated using the MTT assay. The in vitro immunostimulatory effects of maturin acetate (MA) were evaluated on the viability of murine splenocytes and macrophages, and human peripheral blood mononuclear cells (PBMC). The effects of MA on the production of nitrous oxide, pinocytosis and lysosomal enzyme activity were assayed in murine macrophages RAW 264.7. The effects of MA on the NK cell activity were also assayed. The in vivo immunostimulatory activities of MA were evaluated on BALB/c mice immunosuppressed with cyclophosphamide (CY). MA lacks cytotoxic activity against human cancer cells (IC50>200 µM). In the absence of LPS, MA 10 µM or higher stimulated significantly (P≤0.05), compared to untreated cells (-LPS), the viability of murine macrophages and splenocytes. In the absence of LPS, MA 10 µM or higher stimulated significantly (P≤0.05), compared to untreated cells (-LPS), the lysosomal enzyme activity and pinocytosis. In immunosuppressed mice, MA increases significantly (P≤0.05), compared to CY-treated mice, the production of IL-2 and IL-15 and IFN-γ. In conclusion, MA exerts immunostimulatory activities in vitro and in vivo.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sesquiterpenos / Asteraceae / Fatores Imunológicos Limite: Animals / Humans Idioma: En Ano de publicação: 2013 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sesquiterpenos / Asteraceae / Fatores Imunológicos Limite: Animals / Humans Idioma: En Ano de publicação: 2013 Tipo de documento: Article