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RNA helicase signaling is critical for type i interferon production and protection against Rift Valley fever virus during mucosal challenge.
J Virol ; 87(9): 4846-60, 2013 May.
Article em En | MEDLINE | ID: mdl-23408632
Rift Valley fever virus (RVFV) is an emerging RNA virus with devastating economic and social consequences. Clinically, RVFV induces a gamut of symptoms ranging from febrile illness to retinitis, hepatic necrosis, hemorrhagic fever, and death. It is known that type I interferon (IFN) responses can be protective against severe pathology; however, it is unknown which innate immune receptor pathways are crucial for mounting this response. Using both in vitro assays and in vivo mucosal mouse challenge, we demonstrate here that RNA helicases are critical for IFN production by immune cells and that signaling through the helicase adaptor molecule MAVS (mitochondrial antiviral signaling) is protective against mortality and more subtle pathology during RVFV infection. In addition, we demonstrate that Toll-like-receptor-mediated signaling is not involved in IFN production, further emphasizing the importance of the RNA cellular helicases in type I IFN responses to RVFV.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Febre do Vale de Rift / Vírus da Febre do Vale do Rift / Interferon beta / RNA Helicases DEAD-box / Mucosa Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2013 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Febre do Vale de Rift / Vírus da Febre do Vale do Rift / Interferon beta / RNA Helicases DEAD-box / Mucosa Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2013 Tipo de documento: Article