Role of ß-Catenin in regulating the balance between TNF-α- and Fas-induced acute liver injury.
Cancer Lett
; 335(1): 160-7, 2013 Jul 10.
Article
em En
| MEDLINE
| ID: mdl-23410872
ABSTRACT
ß-Catenin plays many critical roles during various liver physiological and pathological processes. However, the role of ß-Catenin in acute liver failure remains unclear. Using hepatocyte specific ß-Catenin knockout mice, we found that loss of ß-Catenin in hepatocyte significantly reduced GalN/LPS-induced liver damage and hepatocyte apoptosis, but exacerbated Jo2-mediated liver injury. Mechanistically, the dual effects of ß-Catenin attributes on its function of inhibiting NF-κB signaling, which aggravates oxidative stress but decreases Fas expression under injury conditions. In conclusion, ß-Catenin plays an important role in regulating the balance between TNF-α and Fas-induced liver injury via its effect on NF-κB.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fator de Necrose Tumoral alfa
/
Receptor fas
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Beta Catenina
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Lesão Pulmonar Aguda
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article