Virus replication as a phenotypic version of polynucleotide evolution.
Bull Math Biol
; 75(4): 602-28, 2013 Apr.
Article
em En
| MEDLINE
| ID: mdl-23413154
ABSTRACT
In this paper, we revisit and adapt to viral evolution an approach based on the theory of branching process advanced by Demetrius et al. (Bull. Math. Biol. 46239-262, 1985), in their study of polynucleotide evolution. By taking into account beneficial effects, we obtain a non-trivial multivariate generalization of their single-type branching process model. Perturbative techniques allows us to obtain analytical asymptotic expressions for the main global parameters of the model, which lead to the following rigorous results:
(i) a new criterion for "no sure extinction", (ii) a generalization and proof, for this particular class of models, of the lethal mutagenesis criterion proposed by Bull et al. (J. Virol. 182930-2939, 2007), (iii) a new proposal for the notion of relaxation time with a quantitative prescription for its evaluation, (iv) the quantitative description of the evolution of the expected values in four distinct "stages" extinction threshold, lethal mutagenesis, stationary "equilibrium", and transient. Finally, based on these quantitative results, we are able to draw some qualitative conclusions.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polinucleotídeos
/
Replicação Viral
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Evolução Molecular
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Modelos Genéticos
Tipo de estudo:
Prognostic_studies
/
Qualitative_research
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article