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Regulated transcription of human matrix metalloproteinase 13 (MMP13) and interleukin-1ß (IL1B) genes in chondrocytes depends on methylation of specific proximal promoter CpG sites.
Hashimoto, Ko; Otero, Miguel; Imagawa, Kei; de Andrés, María C; Coico, Jonathan M; Roach, Helmtrud I; Oreffo, Richard O C; Marcu, Kenneth B; Goldring, Mary B.
Afiliação
  • Hashimoto K; Research Division, Hospital for Special Surgery and Weill Cornell Medical College, New York, New York 10021; Department of Orthopedics, Tohoku University, Sendai 980-8574, Japan.
  • Otero M; Research Division, Hospital for Special Surgery and Weill Cornell Medical College, New York, New York 10021.
  • Imagawa K; Bone and Joint Research Group, Human Development and Health, University of Southampton, Southampton SO16 6YD, United Kingdom.
  • de Andrés MC; Bone and Joint Research Group, Human Development and Health, University of Southampton, Southampton SO16 6YD, United Kingdom.
  • Coico JM; Research Division, Hospital for Special Surgery and Weill Cornell Medical College, New York, New York 10021.
  • Roach HI; Bone and Joint Research Group, Human Development and Health, University of Southampton, Southampton SO16 6YD, United Kingdom.
  • Oreffo ROC; Bone and Joint Research Group, Human Development and Health, University of Southampton, Southampton SO16 6YD, United Kingdom.
  • Marcu KB; Laboratorio di Immunoreumatologia e Rigenerazione Tissutale, Centro di Ricerca Codivilla-Putti, Istituto Ortopedico Rizzoli, 40136 Bologna, Italy; Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York 11794-5215.
  • Goldring MB; Research Division, Hospital for Special Surgery and Weill Cornell Medical College, New York, New York 10021. Electronic address: goldringm@hss.edu.
J Biol Chem ; 288(14): 10061-10072, 2013 Apr 05.
Article em En | MEDLINE | ID: mdl-23417678
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação Enzimológica da Expressão Gênica / Regiões Promotoras Genéticas / Ilhas de CpG / Metilação de DNA / Metaloproteinase 13 da Matriz / Interleucina-1beta Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2013 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação Enzimológica da Expressão Gênica / Regiões Promotoras Genéticas / Ilhas de CpG / Metilação de DNA / Metaloproteinase 13 da Matriz / Interleucina-1beta Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2013 Tipo de documento: Article