The E3-ligase TRIM family of proteins regulates signaling pathways triggered by innate immune pattern-recognition receptors.
Immunity
; 38(2): 384-98, 2013 Feb 21.
Article
em En
| MEDLINE
| ID: mdl-23438823
ABSTRACT
Innate immunity conferred by the type I interferon is critical for antiviral defense. To date only a limited number of tripartite motif (TRIM) proteins have been implicated in modulation of innate immunity and anti-microbial activity. Here we report the complementary DNA cloning and systematic analysis of all known 75 human TRIMs. We demonstrate that roughly half of the 75 TRIM-family members enhanced the innate immune response and that they do this at multiple levels in signaling pathways. Moreover, messenger RNA levels and localization of most of these TRIMs were found to be altered during viral infection, suggesting that their regulatory activities are highly controlled at both pre- and posttranscriptional levels. Taken together, our data demonstrate a very considerable dedication of this large protein family to the positive regulation of the antiviral response, which supports the notion that this family of proteins evolved as a component of innate immunity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
RNA Mensageiro
/
Leucócitos Mononucleares
/
Proteínas de Transporte
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Dedos de Zinco
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Infecções por Rhabdoviridae
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Receptores de Reconhecimento de Padrão
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Imunidade Inata
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article