Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8+ T cells.
Nat Immunol
; 14(4): 356-63, 2013 Apr.
Article
em En
| MEDLINE
| ID: mdl-23475183
ABSTRACT
Immunization results in the differentiation of CD8+ T cells, such that they acquire effector abilities and convert into a memory pool. Priming of T cells takes place via an immunological synapse formed with an antigen-presenting cell (APC). By disrupting synaptic stability at different times, we found that the differentiation of CD8+ T cells required cell interactions beyond those made with APCs. We identified a critical differentiation period that required interactions between primed T cells. We found that T cell-T cell synapses had a major role in the generation of protective CD8+ T cell memory. T cell-T cell synapses allowed T cells to polarize critical secretion of interferon-γ (IFN-γ) toward each other. Collective activation and homotypic clustering drove cytokine sharing and acted as regulatory stimuli for T cell differentiation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Comunicação Celular
/
Diferenciação Celular
/
Subpopulações de Linfócitos T
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Linfócitos T CD8-Positivos
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Sinapses Imunológicas
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article