The endocrinology of exercise.

ABSTRACT

Some obese individuals do not get cardiovascular disease, diabetes, or certain cancers associated with obesity. These healthy obese individuals exercise regularly and reduce circulating levels of inflammatory mediators which are associated with the complications of obesity. Bloated white adipocytes located in ectopic locations such as the liver, produce these inflammatory mediators. Exercise, by reducing the excess storage of fat in these bloated fat cells, reduces the levels of circulating inflammatory mediators. The processes of gathering and creating new energy-rich substances, storing energy, and consuming energy-rich substances, and the specific contribution of several hormones to this process, are reviewed.