(+)-Fluorenylethylchloroformate (FLEC)--improved synthesis for application in chiral analysis and peptidomimetic synthesis.
Org Biomol Chem
; 11(16): 2571-3, 2013 Apr 28.
Article
em En
| MEDLINE
| ID: mdl-23483118
ABSTRACT
An efficient synthesis of the enantiomers of fluorenylethylchloroformate (FLEC) has been achieved that allows the routine application of the reagent for the resolution of chiral amines including unusual amino acids. The utility of the fluorenylethoxycarbonyl (Feoc) group as a chiral Fmoc equivalent, for combined resolution and protection of amino acids, in solid phase peptide synthesis is also shown.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptidomiméticos
/
Fluorenos
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article