Telomere length and cognitive function in southern Chinese community-dwelling male elders.
Age Ageing
; 42(4): 450-5, 2013 Jul.
Article
em En
| MEDLINE
| ID: mdl-23519133
ABSTRACT
BACKGROUND:
telomere attrition has been associated with an increased risk of different age-related diseases and is widely accepted as a marker of cellular ageing. On the other hand, it is well known that cognitive function declines with age. The telomere length may therefore act as a marker for the pathway associated with cognitive function.METHODS:
we examined telomere length and cognitive functions in a community-dwelling Chinese male population aged 65 years and above living in Hong Kong. The telomere length was measured by quantitative real-time PCR in 976 men. Cognitive function was assessed by Chinese (Cantonese) version of Mini-Mental State Exam and Community Screening Interview for Dementia.RESULTS:
our result showed there was a significant association between telomere length, delayed recall (P = 0.007) and category verbal fluency (P = 0.048). These associations remained significant after adjustment for age and education. Further analysis using a cut-off score for MMSE, three-item recall and word list generation tests suggested that the telomere length was positively correlated with performance in these areas (P = 0.015).CONCLUSION:
the findings support the association of telomere length and cognitive function and suggested that the telomere length may serve as a biological marker for cognitive decline.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Telômero
/
Cognição
/
Vida Independente
/
Encurtamento do Telômero
Tipo de estudo:
Prognostic_studies
/
Qualitative_research
Limite:
Aged
/
Aged80
/
Humans
/
Male
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article