Two new oleanane-type triterpenoids from Platycodi Radix and anti-proliferative activity in HSC-T6 cells.

ABSTRACT

Two new oleanane-type triterpenoids, named platycodonoids A and B (1, 2), together with five known saponins, including platycodin D (3), deapioplatycodin D (4), 3-O-ß-D-glucopyranosyl polygalacic acid (5), 3-O-ß-D-glucopyranosyl platycodigenin (6) and polygalacin D (7), were isolated from the roots of Platycodon grandiflorum. On the basis of spectral data and chemical evidence, the structures of the new compounds were elucidated as 2ß,3ß,23,24-tetrahydroxy-28-nor-olean-12-en-16-one (1) and 2ß,3ß,23,24- tetrahydroxy-28-nor-olean-12-en-16-one-3-O-ß-D-glucopyranoside (2). Compounds 1-7 were evaluated for their in vitro anti-proliferative activity against the HSC-T6 cell line.