Three-dimensional structural diversity-oriented peptidomimetics based on the cyclopropylic strain.
Org Lett
; 15(7): 1686-9, 2013 Apr 05.
Article
em En
| MEDLINE
| ID: mdl-23528142
ABSTRACT
Conformationally restricted peptidomimetics comprising eight stereoisomeric scaffolds with three-dimensional structural diversity were designed based on the structural features of cyclopropane, that is, cyclopropylic strain, which mimic wide-ranging tetrapeptide conformations covering ß-turns through ß-strands. Stereoselective synthesis of the designed peptidomimetics led to the identification of nonpeptidic melanocortin-4 receptor ligands.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligopeptídeos
/
Ciclopropanos
/
Peptidomiméticos
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article