3-Bromopyruvate: a novel antifungal agent against the human pathogen Cryptococcus neoformans.
Biochem Biophys Res Commun
; 434(2): 322-7, 2013 May 03.
Article
em En
| MEDLINE
| ID: mdl-23541578
ABSTRACT
We have investigated the antifungal activity of the pyruvic acid analogue 3-bromopyruvate (3-BP). Growth inhibition by 3-BP of 110 strains of yeast-like and filamentous fungi was tested by standard spot tests or microdilution method. The human pathogen Cryptococcus neoformans exhibited a low Minimal Inhibitory Concentration (MIC) of 0.12-0.15 mM 3-BP. The high toxicity of 3-BP toward C. neoformans correlated with high intracellular accumulation of 3-BP and also with low levels of intracellular ATP and glutathione. Weak cytotoxicity towards mammalian cells and lack of resistance conferred by the PDR (Pleiotropic Drug Resistance) network in the yeast Saccharomyces cerevisiae, are other properties of 3-BP that makes it a novel promising anticryptococcal drug.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piruvatos
/
Cryptococcus neoformans
/
Antifúngicos
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article