Statin therapy does not improve lung function in asthma: a meta-analysis of randomized controlled trials.
J Int Med Res
; 41(2): 276-83, 2013 Apr.
Article
em En
| MEDLINE
| ID: mdl-23569033
ABSTRACT
OBJECTIVE:
To assess the efficacy of statins in the treatment of asthma.METHODS:
Electronic databases were searched to identify randomized controlled trials that measured the efficacy of statins in the treatment of asthma, and a meta-analysis of the pooled data was performed.RESULTS:
Five trials were identified; four met the inclusion criteria (total number of patients 200). Compared with controls, patients in the statin groups had higher forced expiratory volume in 1 s (FEV1) values before inhaled corticosteroids (0.09 l, 95% confidence interval [CI] -0.06, 0.23), higher FEV1 values after inhaled corticosteroids (0.06 l, 95% CI -0.09, 0.22), and higher morning peak expiratory flow rates (9.87 l, 95% CI -15.66, 35.40). These results were not statistically significant and, furthermore, publication bias was detected.CONCLUSION:
In conclusion, there is currently insufficient evidence to show that statins improve lung function in patients with asthma.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Asma
/
Ensaios Clínicos Controlados Aleatórios como Assunto
/
Inibidores de Hidroximetilglutaril-CoA Redutases
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article