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A low-grade increase of serum pancreatic exocrine enzyme levels by dipeptidyl peptidase-4 inhibitor in patients with type 2 diabetes.
Tokuyama, Hirotake; Kawamura, Harukiyo; Fujimoto, Masaki; Kobayashi, Kazuki; Nieda, Mie; Okazawa, Tetsuya; Takemoto, Minoru; Shimada, Fumio.
Afiliação
  • Tokuyama H; Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan. hiroppy_hiroppy@yahoo.co.jp
Diabetes Res Clin Pract ; 100(3): e66-9, 2013 Jun.
Article em En | MEDLINE | ID: mdl-23618553
ABSTRACT
A potential adverse effect of dipeptidyl peptidase-4 inhibitors (DPP-4i) on the pancreas remains controversial. We evaluated the DPP-4i effects on pancreatic amylase and lipase activity in patients with type 2 diabetes. These enzymes were slightly but significantly increased, suggesting DPP-4i cause a low-grade inflammatory change in the exocrine pancreas.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 / Inibidores da Dipeptidil Peptidase IV Tipo de estudo: Observational_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2013 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 / Inibidores da Dipeptidil Peptidase IV Tipo de estudo: Observational_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2013 Tipo de documento: Article