Effect of botulinum toxin A on proliferation and apoptosis in the T47D breast cancer cell line.
Asian Pac J Cancer Prev
; 14(2): 891-4, 2013.
Article
em En
| MEDLINE
| ID: mdl-23621257
ABSTRACT
The present study was performed to assess the activity of the botulinum toxin A on breast cancer cells. The T47D cell line was exposed to diverse concentrations of the botulinum toxin A and cell viability and apoptosis were estimated using MTT and propidium iodine/annexin V methods, respectively. Botulinum toxin A exerted greater cytotoxic activity in T47D cells in comparison with MCF10A normal cells; this appeared to be via apoptotic processes caspase-3 and -7. In conclusion, botulinum toxin A induces caspase-3 and -7 dependent apoptotic processes in the T47D breast cancer cell line.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Apoptose
/
Toxinas Botulínicas Tipo A
/
Proliferação de Células
/
Fármacos Neuromusculares
Limite:
Female
/
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article