[Hydrogen sulfide and its effect on pancreatic beta-cells].
Nihon Rinsho
; 71(1): 175-80, 2013 Jan.
Article
em Ja
| MEDLINE
| ID: mdl-23631191
ABSTRACT
Hydrogen sulfide (H2S), a potentially toxic gas, is also an important signaling molecule in various mammalian cells and tissues. H2S is involved in the neuroprotection, neuromodulation, cardioprotection, vasodilatation and the regulation of inflammatory response. In pancreatic beta-cells, H2S can be produced by cystathionine beta-synthase (CBS) or cystathionine gamma-lyase (CSE). The produced H2S inhibits insulin release and regulates beta-cell survival. We demonstrated that glucose stimulation increase CSE expression in mouse pancreatic islets. We also indicated that H2S protects beta-cells that are chronically exposed to high glucose. Loss of beta-cell mass is important in the pathogenesis and/or progression of diabetes mellitus; therefore, molecular analyses of the mechanisms of H2S production and its protective effects on beta-cells may lead to new insights into diabetes mellitus.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pâncreas
/
Diabetes Mellitus
/
Células Secretoras de Insulina
/
Sulfeto de Hidrogênio
/
Insulina
Limite:
Animals
/
Humans
Idioma:
Ja
Ano de publicação:
2013
Tipo de documento:
Article