A phase I trial of sunitinib and rapamycin in patients with advanced non-small cell lung cancer.
Chemotherapy
; 59(1): 8-13, 2013.
Article
em En
| MEDLINE
| ID: mdl-23635552
ABSTRACT
BACKGROUND:
Sunitinib is an oral multitargeted tyrosine kinase inhibitor, with single-agent activity in non-small cell lung cancer (NSCLC). Resistance to tyrosine kinase inhibitor therapy is mediated by the mammalian target of rapamycin (mTOR) pathway, and may be reversed by using mTOR inhibitors.METHODS:
We performed a phase I study evaluating the combination of sunitinib and rapamycin in patients with advanced NSCLC.RESULTS:
Nineteen patients were enrolled in the study. The dose-limiting toxicities included infection, pneumonia, diarrhea/dehydration and treatment delay due to thrombocytopenia in 1 patient each. Sunitinib 25 mg orally daily and rapamycin 2 mg orally daily with 4 weeks on and 2 weeks off therapy were determined to be the maximum tolerated dose. No objective responses were noted, and 6 patients had stable disease as a best response.CONCLUSION:
The combination of sunitinib and rapamycin is well-tolerated and warrants further investigation in the phase II setting.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirróis
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Carcinoma Pulmonar de Células não Pequenas
/
Sirolimo
/
Indóis
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Neoplasias Pulmonares
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Antineoplásicos
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Aged
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Female
/
Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article