Redox balance via lactate dehydrogenase is important for multiple stress resistance and virulence in Enterococcus faecalis.
Infect Immun
; 81(8): 2662-8, 2013 Aug.
Article
em En
| MEDLINE
| ID: mdl-23649090
ABSTRACT
Enterococcus faecalis is a highly stress resistant opportunistic pathogen. The intrinsic ruggedness of this bacterium is supposed to be the basis of its capacity to colonize the hostile environments of hospitals and to cause several kinds of infections. We show in this work that general resistance to very different environmental stresses depends on the ability of E. faecalis to maintain redox balance via lactate dehydrogenase (LDH). Furthermore, LDH-deficient mutants are less successful than the wild type at colonizing host organs in a murine model of systemic infection. Taken together, our results, as well as those previously published for Staphylococcus aureus (A. R. Richardson, S. J. Libby, and F. C. Fang, Science 3191672-1676, 2008), identify LDH as an attractive drug target. These drugs may have additional applications, as in the fight against glycopeptide antibiotic-resistant bacteria and even cancer.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estresse Fisiológico
/
Enterococcus faecalis
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L-Lactato Desidrogenase
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article