Treatment of acute gouty arthritis in complex hospitalized patients with anakinra.
Arthritis Care Res (Hoboken)
; 65(8): 1381-4, 2013 Aug.
Article
em En
| MEDLINE
| ID: mdl-23650178
ABSTRACT
OBJECTIVE:
To report our experience with the efficacy and safety of anakinra for acute gouty arthritis in medically complex hospitalized patients.METHODS:
We reviewed the hospital charts of 26 patients treated with anakinra for crystal-induced arthritis since 2007. Demographics, comorbid conditions, reason for anakinra use, response to treatment, and any adverse outcomes were recorded.RESULTS:
Twenty-six patients received 40 courses of anakinra therapy. In 67% of patients, pain improved significantly within 24 hours, and complete resolution of signs and symptoms of gout occurred by day 5 in 72.5% of patients. Seven patients received multiple courses with no decrement in response with repeated treatments. Anakinra was well tolerated and no adverse outcomes were attributed to the medication. Only 1 patient appeared to be refractory to this form of interleukin-1 inhibition.CONCLUSION:
Anakinra is an effective and safe alternative treatment for acute gouty arthritis in medically complex hospitalized patients who fail or cannot undergo more conventional therapy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artrite Gotosa
/
Antirreumáticos
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Proteína Antagonista do Receptor de Interleucina 1
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Hospitalização
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article