Mitochondrial changes in adenocarcinoma of the pancreas.
Ultrastruct Pathol
; 37(3): 227-31, 2013 May.
Article
em En
| MEDLINE
| ID: mdl-23650995
ABSTRACT
The aim of our study was to analyse the mitochondrial ultrastructure in primary ductal adenocarcinomas of the pancreas and to compare it with normal pancreatic cells. 52 samples of adenocarcinoma of the pancreas obtained by surgical resection or by endosonographic biopsy were examined. Compared to normal mitochondrial ultrastructure in non-tumorous cells, the mitochondria in cancer cells had a dense matrix and condensed configuration or with lucent-swelling matrix associated with disarrangement and distortion of cristae and partial or total cristolysis. Functionally, these structural alterations presume the presence of hypoxia-tolerant and hypoxia-sensitive cancer cells.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
/
Carcinoma Ductal Pancreático
/
Mitocôndrias
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article