Structure-Based Design and Synthesis of an HIV-1 Entry Inhibitor Exploiting X-Ray and Thermodynamic Characterization.

Lalonde, Judith M; Le-Khac, Matthew; Jones, David M; Courter, Joel R; Park, Jongwoo; Schön, Arne; Princiotto, Amy M; Wu, Xueling; Mascola, John R; Freire, Ernesto; Sodroski, Joseph; Madani, Navid; Hendrickson, Wayne A; Smith, Amos B

Lalonde, Judith M; Le-Khac, Matthew; Jones, David M; Courter, Joel R; Park, Jongwoo; Schön, Arne; Princiotto, Amy M; Wu, Xueling; Mascola, John R; Freire, Ernesto; Sodroski, Joseph; Madani, Navid; Hendrickson, Wayne A; Smith, Amos B.

Afiliação

Lalonde JM; Department of Chemistry, Bryn Mawr College, Bryn Mawr, PA 19010.

ACS Med Chem Lett ; 4(3): 338-343, 2013 Mar 14.

Article em En | MEDLINE | ID: mdl-23667716

Palavras-chave

CD4; HIV; entry inhibitor; gp120; protein-protein interactions; structure-based drug design; thermodynamics; viral inhibition; x-ray crystallography

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2013 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2013 Tipo de documento: Article