Sonic hedgehog inhibition induces mouse embryonic stem cells to differentiate toward definitive endoderm.
Indian J Exp Biol
; 51(3): 201-7, 2013 Mar.
Article
em En
| MEDLINE
| ID: mdl-23678540
ABSTRACT
In the experimental group (shh inhibited group), there were significant decreases in the expression of Oct4, Nanog, Shh, GATA4, Brachyury and Goosecoid, while increases were observed for TAT and Pdx1. The expression of Sox17 did not differ between two control and experimental groups. In experimental group, the amount of GSC positive cells was somehow lower but it seems that there was no difference for Sox17. Shh inhibition induces ESCs to differentiate toward definitive endoderm by committing mesendodermal lineages.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Diferenciação Celular
/
Regulação da Expressão Gênica no Desenvolvimento
/
Endoderma
/
Células-Tronco Embrionárias
/
Proteínas Hedgehog
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article