Post-ischemic treatment with L-kynurenine sulfate exacerbates neuronal damage after transient middle cerebral artery occlusion.
Neuroscience
; 247: 95-101, 2013 Sep 05.
Article
em En
| MEDLINE
| ID: mdl-23685169
ABSTRACT
Since brain ischemia is one of the leading causes of adult disability and death, neuroprotection of the ischemic brain is of particular importance. Acute neuroprotective strategies usually have the aim of suppressing glutamate excitotoxicity and an excessive N-methyl-d-aspartate (NMDA) receptor function. Clinically tolerated antagonists should antagonize an excessive NMDA receptor function without compromising the normal synaptic function. Kynurenic acid (KYNA) an endogenous metabolite of the tryptophan metabolism, may be an attractive neuroprotectant in this regard. The manipulation of brain KYNA levels was earlier found to effectively enhance the histopathological outcome of experimental ischemic/hypoxic states. The present investigation of the neuroprotective capacity of L-kynurenine sulfate (L-KYNs) administered systemically after reperfusion in a novel distal middle cerebral artery occlusion (dMCAO) model of focal ischemia/reperfusion revealed that in contrast with earlier results, treatment with L-KYNs worsened the histopathological outcome of dMCAO. This contradictory result indicates that post-ischemic treatment with L-KYNs may be harmful.
Palavras-chave
3-HK; 3-hydroxykynurenine; CNS; EEG; I/H; KYNA; L-KYNs; L-kynurenine sulfate; MCAO model; N-methyl-d-aspartate; N-methyl-d-aspartate receptors; NDS; NMDA; NMDAR; PB; QUIN; central nervous system; dMCA; dMCAO; distal middle cerebral artery; distal middle cerebral artery occlusion; electroencephalography; focal cerebral ischemia; glycine co-agonist site; ischemic/hypoxic; kynurenic acid; kynurenines; neuroprotection; normal donkey serum; phosphate buffer; quinolinic acid
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infarto da Artéria Cerebral Média
/
Cinurenina
/
Neurônios
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article