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Synthesis of acylguanidine zanamivir derivatives as neuraminidase inhibitors and the evaluation of their bio-activities.
Lin, Chien-Hung; Chang, Tsung-Che; Das, Anindya; Fang, Ming-Yu; Hung, Hui-Chen; Hsu, Kai-Cheng; Yang, Jinn-Moon; von Itzstein, Mark; Mong, Kwok Kong T; Hsu, Tsu-An; Lin, Chun-Cheng.
Afiliação
  • Lin CH; Department of Chemistry, National Tsing Hua University, 101, Section 2, Kuang-Fu Road, Hsinchu 30013, Taiwan.
Org Biomol Chem ; 11(24): 3943-8, 2013 Jun 28.
Article em En | MEDLINE | ID: mdl-23695381
A series of acylguanidine-modified zanamivir analogs were synthesized and their inhibitory activities against the NAs of avian influenza viruses (H1N1 and H3N2) were evaluated. In particular, zanamivir derivative , with a hydrophobic naphthalene substituent, exhibits the best inhibitory activity against group-1 NA with an IC50 of 20 nM.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Guanidina / Inibidores Enzimáticos / Zanamivir / Neuraminidase Idioma: En Ano de publicação: 2013 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Guanidina / Inibidores Enzimáticos / Zanamivir / Neuraminidase Idioma: En Ano de publicação: 2013 Tipo de documento: Article