[Therapeutic response of Plasmodium vivax to chloroquine in Bolivia]. / Respuesta terapéutica de Plasmodium vivax a la cloroquina, en Riberalta, Guayaramerín y Yacuiba, Bolivia.
Biomedica
; 32(4): 527-35, 2012.
Article
em Es
| MEDLINE
| ID: mdl-23715228
ABSTRACT
INTRODUCTION:
Knowledge of the therapeutic efficacy of chloroquine for Plasmodium vivax infections improves the capacity for surveillance of anti-malarial drug resistance.OBJECTIVE:
The therapeutic efficacy of chloroquine as treatment was evaluated for uncomplicated Plasmodium vivax malaria in Bolivia. MATERIALS ANDMETHODS:
An in vivo efficacy study of chloroquine was undertaken in three regions of Bolivia--Riberalta, Guayaramerín and Yacuiba. Two hundred and twenty-three patients (84, 80, and 59 in the three regions, respectively) aged over 5 years old were administered with chloroquine (25 mg/kg/three days) and followed for 28 days. Blood levels of chloroquine and desethylchloroquine were measured on day 2 and on the day of reappearance of parasitemia. The cumulative incidence of treatment failure was calculated using the Kaplan and Meier survival analysis.RESULTS:
The mean parasitemias (asexual) on day 0 were 6,147 parasites/µl of blood in the Riberalta population, 4,251 in Guayaramerín and 5,214 in Yacuiba. The average blood concentrations of chloroquine-desethylchloroquine during day 2 were 783, 817, and 815 ng/ml, respectively. No treatment failures were observed in Yacuiba, whereas in Riberalta and Guayaramerín, the frequencies of treatment failures were 6.2% and 10%. Blood levels of chloroquine and desethylchloroquine in patients with treatment failure showed values below 70 ng/ml on the day of reappearance of parasitemia.CONCLUSION:
Resistance of Plasmodium vivax to chloroquine was not demonstrated in three regions of Bolivia.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasmodium vivax
/
Cloroquina
/
Malária Vivax
/
Parasitemia
/
Antimaláricos
Tipo de estudo:
Clinical_trials
Limite:
Adolescent
/
Adult
/
Animals
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
/
Middle aged
/
Pregnancy
País/Região como assunto:
America do sul
/
Bolivia
Idioma:
Es
Ano de publicação:
2012
Tipo de documento:
Article