Defective synaptic transmission and structure in the dentate gyrus and selective fear memory impairment in the Rsk2 mutant mouse model of Coffin-Lowry syndrome.
Neurobiol Dis
; 58: 156-68, 2013 Oct.
Article
em En
| MEDLINE
| ID: mdl-23742761
Palavras-chave
90-kDa ribosomal S6 kinase; AMPAr; CLS; CREB; CS; CoffinLowry; CoffinLowry syndrome; Conditioned stimulus; EM; EPSC; ERK; Electron microscopy; Excitatory postsynaptic currents; Extracellular signal-regulated kinase; Field excitatory postsynaptic potential; GluR; Glutamate receptor; Hippocampus; IEG; ISI; ITI; Immediate early gene; Intellectual disability; Inter-stimulus interval; Inter-trial interval; LTP; Long-term potentiation; MPP; MSB; MSK1/2; Medial perforant path; Mental retardation; Metabotropic glutamate receptor; Mitogen stress-activated kinase 1 and 2; Multiple spine bouton; N-methyl-d-aspartate receptor; NMDAr; PPF; PPI; PSD; PTP; Paired-pulse facilitation; Paired-pulse inhibition; Post-tetanic potentiation; Postsynaptic density; RSK; Reconsolidation; STP; Short-term potentiation; Synaptic morphology; Synaptic plasticity; Trace fear conditioning; Transcription factors; US; Unconditioned stimulus; WT; Wild-type; cAMP-response element binding protein; fEPSP; mGluR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transmissão Sináptica
/
Giro Denteado
/
Síndrome de Coffin-Lowry
/
Proteínas Quinases S6 Ribossômicas 90-kDa
/
Medo
/
Transtornos da Memória
/
Mutação
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article