Adult renal mesenchymal stem cell-like cells contribute to juxtaglomerular cell recruitment.
J Am Soc Nephrol
; 24(8): 1263-73, 2013 Jul.
Article
em En
| MEDLINE
| ID: mdl-23744888
ABSTRACT
The renin-angiotensin-aldosterone system (RAAS) regulates BP and salt-volume homeostasis. Juxtaglomerular (JG) cells synthesize and release renin, which is the first and rate-limiting step in the RAAS. Intense pathologic stresses cause a dramatic increase in the number of renin-producing cells in the kidney, termed JG cell recruitment, but how this occurs is not fully understood. Here, we isolated renal CD44(+) mesenchymal stem cell (MSC)-like cells and found that they differentiated into JG-like renin-expressing cells both in vitro and in vivo. Sodium depletion and captopril led to activation and differentiation of these cells into renin-expressing cells in the adult kidney. In summary, CD44(+) MSC-like cells exist in the adult kidney and can differentiate into JG-like renin-producing cells under conditions that promote JG cell recruitment.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistema Renina-Angiotensina
/
Captopril
/
Diferenciação Celular
/
Renina
/
Células-Tronco Adultas
/
Células-Tronco Mesenquimais
/
Sistema Justaglomerular
/
Rim
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article