Maternal smoking during pregnancy and neural tube defects in offspring: a meta-analysis.
Childs Nerv Syst
; 30(1): 83-9, 2014 Jan.
Article
em En
| MEDLINE
| ID: mdl-23760473
ABSTRACT
PURPOSE:
This study aims to examine the association between maternal smoking during pregnancy and neural tube defects (NTDs) in offspring.METHODS:
We retrieved published studies on the association between maternal smoking during pregnancy and NTDs risk in offspring. Meta-analysis was applied to calculate the overall odds ratios (ORs) and their 95 % confidence intervals (CIs). The publication bias was assessed by the Egger's regression asymmetry test and Begg's rank correlation test.RESULTS:
The overall effect of maternal smoking during pregnancy on NTDs was 1.03 (OR = 1.03, 95 % CI = 0.80-1.33). When subgroup analysis was conducted by geographic regions, the overall effects were 1.39 (OR = 1.39, 95 % CI = 1.18-1.64), 0.88 (OR = 0.88, 95 % CI = 0.66-1.17) in Europe and USA; when subgroup analysis was conducted by NTDs types, the overall effect was 1.55 (OR = 1.55, 95 % CI = 1.06-2.26) for spina bifida.CONCLUSIONS:
Women who smoked during pregnancy had mildly elevated risk of having infants with NTDs.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Efeitos Tardios da Exposição Pré-Natal
/
Fumar
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Defeitos do Tubo Neural
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
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Observational_studies
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Risk_factors_studies
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Systematic_reviews
Limite:
Female
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Humans
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Newborn
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Pregnancy
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article