Clinical consequences of targeting IL-17 and TH17 in autoimmune and allergic disorders.
Curr Allergy Asthma Rep
; 13(6): 587-95, 2013 Dec.
Article
em En
| MEDLINE
| ID: mdl-23760974
ABSTRACT
The TH17 lineage of T cells and its canonical cytokine IL-17 have been the focus of many recent studies in autoimmune, allergic, and infectious disease. In this review, we will briefly discuss the current knowledge about the role of these cells and IL-17 in a spectrum of disorders. It is clear that IL-17 plays pathogenic roles in certain conditions while the same pathway is critically important to immunity in others. Targeting of TH17 cells or IL-17 therapeutically may impart many benefits, but this approach is not without potentially serious implications regarding host defense. These issues will be discussed herein as we evaluate pharmacological approaches targeting this pathway that are just beginning to be fully tested in human disease.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Asma
/
Doenças Autoimunes
/
Interleucina-17
/
Células Th17
/
Hipersensibilidade
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article