[Intractable diarrhoea and severe weight loss by roflumilast]. / Diarrea intratable y pérdida ponderal acusada secundarias a roflumilast.
Med Clin (Barc)
; 141(3): 116-8, 2013 Aug 04.
Article
em Es
| MEDLINE
| ID: mdl-23768858
ABSTRACT
BACKGROUND AND OBJECTIVE:
Roflumilast is a recently marketed drug, indicated for maintenance treatment of severe chronic obstructive pulmonary disease associated with chronic bronchitis in adult patients with a history of frequent exacerbations as add on to bronchodilator treatment. MATERIAL ANDMETHODS:
The safety data of this drug have always been subjected to controversy and concerns. The Food and Drug Administration rejected the drug after the first evaluation, asking the company to clarify the adverse reactions during the investigation process, the European Medicines Agency approved the drug including a Risk Management Plan, designed to promote a safe use of the drug.RESULTS:
During the first months after the marketing process, the Spanish Pharmacovigilance System has already been acquainted of several adverse events notifications; therefore, these patients may be closely monitored, mainly because of digestive and psychiatric disorders.CONCLUSIONS:
Here we report the case of a female patient who showed a serious digestive clinical profile and a severe weight loss, more than 25% of her initial weight, when a treatment with roflumilast was started. The suspicion of a side effect as the cause of the reported clinical profile and its resolution required 3 hospital admissions.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inibidores de Fosfodiesterase
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Benzamidas
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Doença Pulmonar Obstrutiva Crônica
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Diarreia
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Aminopiridinas
Limite:
Aged
/
Animals
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Female
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Humans
Idioma:
Es
Ano de publicação:
2013
Tipo de documento:
Article